Intraoperative Floppy Iris Syndrome in Korean Patients Taking α1-Adrenergic Receptor Antagonists

Samsung Medical Center

Status: Completed

Conditions: Intraoperative Floppy Iris Syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT01704014

2010-01-034

Details and patient eligibility

About

Intraoperative floppy iris syndrome (IFIS) is a recently described condition observed during cataract surgery. It has been hypothesized that irreversible atrophy of the iris dilator muscle associated with α1-adrenergic receptor antagonists (α1-ARA) is responsible for IFIS. However the prevalence of IFIS in Korean population is not reported. The purpose of this study is to evaluate the prevalence and clinical manifestations of IFIS in relation to iris anatomical change in Korean patients taking α1-ARA.

Enrollment: 150 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• clinical diagnosis of cataract
• korean patients

Exclusion criteria

• history of iridocyclitis, iris neovascularization, or prior iris surgery
• traumatic cataracts, zonular dialysis, or cataracts associated with ocular disease (e.g., uveitis)

Trial design

150 participants in 2 patient groups

α1-ARA Group

Description:

All patients on α1-ARA(α1-adrenergic receptor antagonists) medication who underwent cataract surgeries.

Control Group

Description:

Age and sex-matched control subjects