Intraoperative Heart Rate Thresholds and Postoperative Mortality

Asan Medical Center

Status: Completed

Conditions: HEART RATE

Treatments: Other: Intraoperative Heart Rate Monitoring

Study type: Observational

Funder types: Other

Identifiers

NCT07075744

AMC [2023-0611]

Details and patient eligibility

About

This retrospective observational study investigates the association between intraoperative heart rate and 30-day postoperative mortality among patients undergoing non-cardiac surgery. The findings suggest that heart rate abnormalities during surgery may significantly affect short-term postoperative outcomes.

Full description

This is a retrospective cohort study conducted to evaluate the clinical impact of intraoperative heart rate on postoperative 30-day mortality in patients undergoing non-cardiac surgery. Patient data were extracted from a large institutional electronic medical record database, including demographic variables, comorbidities, anesthesia records, and perioperative outcomes.

Heart rate was continuously recorded at 1-minute or 5-minute intervals during the surgery. Various heart rate parameters-such as minimum, maximum, average, and time-weighted average-were analyzed, and threshold-based metrics (e.g., minutes spent below or above defined thresholds) were computed using a piecewise cubic Hermite interpolating polynomial (PCHIP) method to smooth minute-by-minute fluctuations.

The primary outcome was all-cause mortality within 30 days after surgery. Multivariable logistic regression and sensitivity analyses were performed to adjust for potential confounders. The study aimed to provide clinical insight into the prognostic value of intraoperative heart rate dynamics and to identify modifiable intraoperative risk factors for mortality.

Enrollment: 139,149 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who underwent non-cardiac surgery at our medical center between March 2019 and February 2023
• Age ≥ 18 years
• Availability of complete laboratory data and perioperative vital signs
• Only the first surgery performed after hospital admission was included for patients with multiple

Exclusion criteria

• Cardiac-related surgical procedures
• Pregnancy at the time of surgery
• Age < 18 years
• Surgeries lasting less than 30 minutes
• Cadaveric procedures
• Missing or incomplete laboratory values or vital sign data

Trial design

139,149 participants in 1 patient group

Non-cardiac Surgery Cohort

Description:

This cohort includes adult patients who underwent non-cardiac surgery under general or regional anesthesia. The study retrospectively examined intraoperative heart rate patterns and their association with postoperative 30-day mortality. No intervention was applied as this is an observational study.

Treatment:

Other: Intraoperative Heart Rate Monitoring