Intraoperative Ketamine and Magnesium Therapy for Control of Postoperative Pain After a Liposuction and Lipoabdominoplasty (KEMPLA)

University of Chile

Status: Completed

Conditions: Pain, Postoperative

Treatments: Drug: Ketamine + magnesium; Drug: Saline; Drug: Ketamine

Study type: Interventional

Funder types: Other

Identifiers

NCT02450214

OAIC N 722/15

Details and patient eligibility

About

Lipoabdominoplasty and liposuction are one of the most common plastic surgeries. The management of postoperative pain is complex. Non Steroidal Anti Inflammatory Drugs (NSAIDs) are insufficient, while opioids are avoided by their adverse effects and regional techniques are hampered by a premature discharge. In this context, the investigators seek an intraoperative multimodal analgesic technique blocking NMDA receptors with ketamine plus magnesium to significantly decrease postoperative pain.

Enrollment: 63 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Female and male
• 18 years or older
• Liposuction and lipoabdominoplasty
• ASA 1 and 2
• BMI 21-28 Kg/m2
• Full secondary education

Exclusion criteria

• Patients with surgeries added to the main proceedings
• Scheduled to tuck in Flor de Lis or Body Lift
• History of use of analgesic drugs 48 hours before surgery
• Peripheral central neurological diseases
• Known allergy will be excluded to medication in use in this study (ketamine, magnesium, clindamycin and penicillin or other)

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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63 participants in 3 patient groups

Control group (C)

Sham Comparator group

Description:

50 mL syringe with saline, plus 1 flask of 100 mL saline (Saline)

Treatment:

Drug: Saline

Ketamine group (K)

Experimental group

Description:

50 mL syringe with ketamine (50mg / 50ml), plus 1 flask of 100 mL saline (Ketamine)

Treatment:

Drug: Ketamine

Magnesium + ketamine group (MGK)

Experimental group

Description:

50mL syringe with ketamine (50mg / 50ml), plus a flask of 100ml of saline with 5 g of magnesium sulfate (Ketamine + magnesium)

Treatment:

Drug: Ketamine + magnesium