Intraoperative Norepinephrine Versus Fresh Frozen Plasma in Patients Undergoing HIPEC to Reduce Renal Insult

National Cancer Institute, Egypt

Status: Completed

Conditions: Anesthesia

Treatments: Drug: Norepinephrine; Biological: Fresh frozen plasma

Study type: Interventional

Funder types: Other

Identifiers

NCT04683614

201920025.2P

Details and patient eligibility

About

comparing the effect of low dose norepinephrine infusion versus fresh frozen plasma in patients undergoing HIPEC to reduce renal insult

Full description

To compare the efficacy of maintaining intraoperative hemodynamic stability through infusing low dose norepinephrine versus fresh frozen plasma in patients undergoing cytoreductive surgery and heated intraperitoneal chemotherapy in cancer patients undergoing cytoreductive surgery and heated intraperitoneal chemotherapy

Enrollment: 60 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA I and II
• World Health Performance Status ≤2
• scheduled for CRS/HIPEC operations

Exclusion criteria

• patient's refusal
• allergy to any of the used drugs
• impaired renal or liver functions

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

Fresh frozen plasma

Experimental group

Description:

early administration of fresh frozen plasma

Treatment:

Biological: Fresh frozen plasma

Low dose norepinephrine

Experimental group

Description:

low dose epinephrine 5 mic/kg/hr

Treatment:

Drug: Norepinephrine