Intraoperative "p50" Measurement in Liver Transplant Surgeries

Inonu University

Status: Invitation-only

Conditions: Liver Transplant; Complications

Study type: Observational

Funder types: Other

Identifiers

NCT06660095

Inonu p50

Details and patient eligibility

About

The aim of this study is to compare the p50 value in routine blood gas measurements taken during liver transplant surgery follow-up with other follow-up parameters and clinical findings on the monitors, and to investigate whether there is a predictive parameter that can predict the rapidly changing clinical findings of the patients.

Full description

Blood gas monitoring is the most commonly method used by anesthetists during liver transplant surgeries. We evaluated the blood gas p50 value according to the stages in these heart transplant operations. We tried to find out how the blood gas p50 value would guide the patient's clinical findings in the dissection phase, anhepatic phase and neohepatic phase. For this purpose, we compared arterial and venous blood gas p50 values with the patient's vital signs at certain stages in liver transplant surgeries.

Enrollment: 25 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Liver transplant recipients who will undergo Elective Liver Transplant surgery at İnönü University Faculty of Medicine Liver Transplant Institute, ASA (American Society of Anesthesiology) score III-IV, patients between the ages of 18-65

Exclusion criteria

• Patients with fulminant liver failure,
• hepatic encephalopathy,
• hepatorenal,
• hepatopulmonary syndrome,
• uncontrolled diabetes mellitus,
• cardiovascular, pulmonary disease,
• sepsis
• and patients who refuse consent in the informed consent form will be excluded from the study.

Trial design

25 participants in 1 patient group

Liver transplant recipients

Description:

T0: After the anesthesia induction, before the surgery T1: Intraoperative p50 value from the blood gas sample taken during the dissection stage T2: Intraoperative p50 value from the blood gas sample taken during the anhepatic stage T3: Intraoperative p50 value from the blood gas sample taken during the neohepatic stage T4: After the hepatic artery reperfusion T5: At the end of the surgery