Intraoperative Pleth Variability Index (PVI) Variability

University of California San Francisco (UCSF)

Status: Terminated

Conditions: Intraoperative Monitoring

Study type: Observational

Funder types: Other

Identifiers

NCT03215238

PT1701

Details and patient eligibility

About

Pleth Variability Index (PVI) is a variable that is derived from photoplethysmography (PPG) signal. It is used as a surrogate for intravascular volume status intraoperatively. PVI can have significant amount of baseline variability which appears to oscillate at a very low frequency (5-10 minute cycles). This study aims to investigate the origin of these baseline oscillations.

Full description

PVI is derived from the infrared photoplethysmography signal. Intraoperatively during mechanical ventilation it reflect fluid responsiveness which is a surrogate endpoint of intravascular volume.

PVI signal appears to have significant baseline variability which can not be explained by rapid changes in intravascular fluid volume. The baseline PVI changes also appear to oscillate at a very low frequency, much below any previously identified spontaneous vascular oscillations.

The aim of this study is to investigate weather the PVI variability originates from changes in the infrared photoplethysmography signal or if they are possibly due to the algorithm calculating PVI.

Enrollment: 10 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Neurosurgical patients for tumor resection
• neurointerventional patients
• general anesthesia with mechanical ventilation
• communicates in english (consent)
• over 18 years of age

Exclusion criteria

• unable to sign consent
• less than 18 years of age

Trial design

10 participants in 2 patient groups

neurosurgical patients

Description:

Neurosurgical patients undergoing craniotomies for tumor. 25 subjects

Neurointerventional patients

Description:

Patients undergoing neurointerventional procedures under general anesthesia. 25 subjects