Intraoperative Renal Desaturation and Postoperative Acute Kidney Injury

C

Chinese PLA General Hospital (301 Hospital)

Status

Completed

Conditions

Postoperative Acute Kidney Injury

Treatments

Device: Near-infrared spectroscopy

Study type

Observational

Funder types

Other

Identifiers

NCT04967105
PLAGH-AOC-003

Details and patient eligibility

About

The aim of this study is to investigate the changes in renal regional oxygen saturation (rSO2) monitored by near-infrared spectroscopy (NIRS) and its relationship with the occurrence of postoperative AKI.

Full description

Postoperative acute kidney injury (AKI) is a severe complication after liver resection and contributes to increased morbidity and mortality. Advanced age reduces renal autoregulatory capacity due to physiological and functional changes, thus render the elderly to suffer postoperative AKI and probably the consequent chronic kidney disease. Thus, it is essential to identify those patients at high risk to develop postoperative AKI to optimize perioperative prevention and protection strategies. Despite the multiple risk factors and potential mechanisms that have been identified, the diagnosis of postoperative AKI depending on serum creatinine changes have been delayed for early identification of postoperative AKI. It is of great interest to develop target strategies for close motoring of renal function. This study is a prospective cohort study to investigate the associations between intraoperative renal desaturation measured by NIRS and postoperative AKI. The investigators intend to access the optimal threshold values of renal rSO2 for predicting postoperative AKI. Desaturation of renal rSO2 will be defined by the severity and duration of NIRS values during the surgical process. The principal clinical outcome of the study is postoperative AKI, defined as an absolute increase in serum creatinine of 0.3 mg/dL within 48 hours or a 1.5-fold increase from preoperative baseline within seven days after surgery, according to the Kidney Disease: Improving Global Outcomes (KDIGO) criterion.

Enrollment

157 patients

Sex

All

Ages

60 to 100 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Elderly patients (defined as 60 years of age or older) scheduled for elective liver resection

Exclusion criteria

  • Emergency surgery
  • Liver transplantation
  • Preoperative hemodialysis
  • BMI > 30
  • Renal depth (distance from the capsule of the kidney to the skin surface) > 4 cm
  • Unable or failed to sign the informed consent

Trial design

157 participants in 1 patient group

elderly patients following liver resection
Description:
elderly patients (aged ≥60 years) scheduled for any type of liver resection due to benign or malignant hepatobiliary diseases
Treatment:
Device: Near-infrared spectroscopy

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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