Intraoperative Sedation and Postoperative Delirium

Seoul National University

Status: Completed

Conditions: Orthopedics

Treatments: Drug: Propofol; Drug: Dexmedetomidine

Study type: Observational

Funder types: Other

Identifiers

NCT02573558

B-1510/318-104

Details and patient eligibility

About

Delirium are common after orthopedic surgery in the elderly and are directly associated with loss of independence, reduction in the quality of life and increased mortality. The cause of postoperative delirium still remains unclear and may be multifactorial. The aim of this retrospective study is to examine prevalence of postoperative delirium according to the use of dexmedetomidine or propofol in elderly patients undergoing orthopedic surgery under regional anesthesia.

Enrollment: 855 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who underwent orthopedic surgery under regional anesthesia
• age of 65 years or greater

Exclusion criteria

• General anesthesia
• age < 65 years
• central nervous system disease, including dementia and Parkinson's disease
• Patients who were not received sedation with propofol or dexmedetomidine during the operation

Trial design

855 participants in 2 patient groups

DEX

Description:

patients who received dexmedetomidine during the operation

Treatment:

Drug: Dexmedetomidine

PPF

Description:

patients who received propofol during the operation

Treatment:

Drug: Propofol