Intraoperative Sedatives and Postoperative Pain

Seoul National University

Status and phase: Completed; Phase 4

Conditions: Arthritis, Degenerative

Treatments: Drug: Dexmedetomidine; Drug: Propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT02784626

B-1603/339-005

Details and patient eligibility

About

In this study, based on the hypothesis that dexmedetomidine administered intraoperatively for sedation can reduce postoperative pain than that of propofol, the investigators examined the ability of dexmedetomidine to reduce postoperative pain in in patients undergoing the total knee arthroplasty.

Enrollment: 48 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing total knee arthroplasty
• Age: 20 - 80 yrs

Exclusion criteria

• ASA classification ≥ 3
• Patient who do not want sedation during the surgery
• Patient who wants general anesthesia
• Cardiovascular disease
• Liver dysfunction
• Renal dysfunction

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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48 participants in 2 patient groups

Dexmedetomidine

Experimental group

Description:

Patients who received dexmedetomidine during the operation

Treatment:

Drug: Dexmedetomidine

Propofol

Experimental group

Description:

Patients who received propofol during the operation

Treatment:

Drug: Propofol