Intraoperative Subanesthetic Ketamine Versus Dexmedetomidine Infusion for Prevention of Post-traumatic Stress Disorder After Traumatic Brain Surgeries

Zagazig University

Status: Invitation-only

Conditions: Subanesthetic Ketamine Dexmedetomidin

Treatments: Drug: dexmedetomidine; Drug: ketamine

Study type: Interventional

Funder types: Other

Identifiers

NCT06498700

440

Details and patient eligibility

About

Prevention of Post-traumatic Stress Disorder after traumatic Brain surgeries by using either subanesthetic ketamine or dexmedetomidine infusion.

Full description

after being informed about the study and potential risks. All patients giving written consent will be randomized by double blind manner into two equal groups (K group and D group). Using computer generated randomization table; each group consists of 26 patients: K group (n=26): Patient will receive with 0.5 mg/kg/h ketamine infusion. D group (n=26): Patient will receive 0.1 ug/kg/h dexmedetomidine infusion.

Enrollment: 52 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Aged 18-60 years old.Body mass index of less than or equal 35.American Society of I and II.Duration of surgery not more than 3 hours.

Exclusion criteria

Known hypersensitivity to dexmedetomidine or ketamine. Hemorrhagic shock decompensation.History of alcohol or drug abuse.History of neurologic or psychiatric diseases Advanced renal ,liver or cardiovascular disorders.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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52 participants in 2 patient groups

Ketamine(K)

Experimental group

Description:

0.5 mg/kg/h ketamine infusion

Treatment:

Drug: ketamine

dexmedetomidine(D)

Experimental group

Description:

0.1 ug/kg/h dexmedetomidine infusion

Treatment:

Drug: dexmedetomidine