Intraoperative Volume Management and QT Interval

Technische Universität Dresden

Status: Unknown

Conditions: Blood Loss, Surgical

Treatments: Procedure: intra-operative blood loss

Study type: Observational

Funder types: Other

Identifiers

NCT02441751

EK110032015

Details and patient eligibility

About

QT interval changes is measured during all phases of the operation. The protocol is focusing at intraoperative bleeding events and is also observing QT interval changes during anesthetic and operative procedures.

Full description

Prolongation of the QT interval is associated with functional torsade de points, re-entry, and sudden death (see reference). Variations of QT-interval caused by changes in the volume status of the patient during an operation remained unclear. QT interval changes will be monitored during the surgery with the focus of the influence of sudden blood loss, volume substitution by crystalloids, blood and blood products. The effect of surgical procedures on the QT-interval (e.g. clamping of kidney artery) will be observed as well as the association of intra-operative QT-interval alterations with postoperative complications.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists physical status classification 2 - 3
• patients after consent

Exclusion criteria

• Children,
• pregnant women,
• patients not able to consent

Trial design

200 participants in 2 patient groups

bleeding

Description:

intraoperative blood loss \> 500 ml

Treatment:

Procedure: intra-operative blood loss

no bleeding

Description:

intraoperative blood loss \< 500 ml