Intraoperative vs. Postoperative Intravesical Epirubicin Instillation for Prevention of Bladder Recurrence in High-Risk Upper Urinary Tract Urothelial Carcinoma (IEPBR)

Ankara Etlik City Hospital

Status: Completed

Conditions: Upper Urinary Tract Carcinoma; Intravesical Instillation; Bladder Cancer Recurrence

Study type: Observational

Funder types: Other

Identifiers

NCT06941038

E2-21-421

Details and patient eligibility

About

Upper urinary tract urothelial carcinoma (UTUC) accounts for 5%-10% of urothelial malignancies, with up to 50% of patients developing bladder recurrence post-RNU. High-risk UTUC (≥pT2, high-grade, or N+ disease) necessitates aggressive management. Intravesical chemotherapy mitigates recurrence risk, yet optimal timing-intraoperative vs. postoperative-remains unclear. This study evaluates intraoperative epirubicin instillation during RNU compared to postoperative administration and no instillation.

Enrollment: 270 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• primary high-risk UTUC.

Exclusion criteria

• prior bladder cancer,
• low-risk UTUC (managed conservatively),
• metastatic disease,
• incomplete follow-up