Intraosseous PRP for Knee Osteoarthritis: Pilot Study

Unidad de Cirugía Artroscópica

Status and phase

Completed

Phase 2

Conditions

Knee Osteoarthritis

Treatments

Biological: Platelet Rich Plasma

Study type

Interventional

Funder types

Other

Identifiers

NCT03160781

UCA-01-EC/13/ART

Details and patient eligibility

About

The aim of this study was to assess a novel approach to treating severe knee osteoarthritis by targeting synovialmembrane, superficial articular cartilage, synovial fluid, and subchondral bone by combining intra-articular injections and intraosseous infiltrations of platelet rich plasma.This study explored a new strategy consisting of intraosseous infiltrations of platelet rich plasma into the subchondral bone in combination with the conventional intra-articular injection in order to tackle several knee joint tissues simultaneously.

Enrollment

19 patients

Sex

All

Ages

40 to 77 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients of both sexes aged 40 to 77 years.
Predominant internal tibiofemoral knee osteoarthritis.
Joint pain above 2.5 VAS points.
Radiographic severity degrees 3 and 4 according to Ahlbäck scale.
Values of body mass index between 20 and 33.
Possibility for observation during the follow-up period.

Exclusion criteria

Bilateral knee osteoarthritis which requires infiltration in both knees.
Values of body mass index > 33.
Polyarticular disease diagnosed.
Severe mechanical deformity (diaphyseal varus of 4∘ and valgus of 16∘).
Arthroscopy in the last year prior to treatment.
Intra-articular infiltration of hyaluronic acid in the past 6 months.
Systemic autoimmune rheumatic disease (connective tissue diseases and systemic necrotizing vasculitis).
Poorly controlled diabetes mellitus (glycosylated hemoglobin above 9%).
Blood disorders (thrombopathy, thrombocytopenia, and anemia with Hb < 9).
Undergoing immunosuppressive therapy and/or warfarin.
Treatment with corticosteroids during the 6 months prior to inclusion in the study.