Intraperitoneal Instillation of Levobupivacaine With Morphine Versus Levobupivacaine With Magnesium Sulfate for Postoperative Analgesia

Sohag University

Status and phase: Completed; Phase 4

Conditions: Post Operative Pain

Treatments: Drug: intraperitoneal levobupivacaine and morphine

Study type: Interventional

Funder types: Other

Identifiers

NCT05281081

Soh-Med-22-02-27

Details and patient eligibility

About

This is a prospective randomized study that included 60 patients and was divided into two equal groups of patients who were scheduled for LC, Ages 18 and 60 years, both sexes, ASA I-II and BMI 19 - 39. Group A received 30 ml levobupivacaine (0.25%) plus 3 mg morphine intraperitoneal at the site of surgery in the bed of the gallbladder via the navel port with the patient in a Trendelenburg position, Group B received 30 ml levobupivacaine (0.25%) plus 50 mg/kg magnesium sulfate in the same pattern as in the A group.

Enrollment: 60 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who were scheduled for L.C,
• Ages 18 and 60 years
• ASA I-II and
• BMI 19 - 39

Exclusion criteria

• Patients with hepatic or renal dysfunction
• use of opioids 24 hrs prior to the study
• treatment with steroids prior to surgery
• drug or alcohol abuse, allergy to any of the study drugs
• chronic pain syndrome as a result of neurological disease

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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60 participants in 2 patient groups

levobupivacaine with morphine

Active Comparator group

Description:

30 patients will have intraperitoneal instillation of levobupivacaine with added morphine at the end of laparoscopic cholecystectomy operation

Treatment:

Drug: intraperitoneal levobupivacaine and morphine

levobupivacaine with magnesium sulfate

Experimental group

Description:

30 patients will have intraperitoneal instillation of levobupivacaine with added magnesium sulfate at the end of laparoscopic cholecystectomy operation

Treatment:

Drug: intraperitoneal levobupivacaine and morphine