Intrathecal Atropine to Prevent Postoperative Nausea and Vomiting

Assiut University

Status: Completed

Conditions: Postoperative Nausea

Treatments: Drug: dexamethasone; Drug: Intrathecal atropine

Study type: Interventional

Funder types: Other

Identifiers

NCT03387956

IRB00009916

Details and patient eligibility

About

optimal postoperative pain control with intrathecal morphine, with proper prevention of postoperative nausea and vomiting. Dexamethasone, and or atropine could offer some protection against nausea and vomiting.

Full description

One of the gold standards for analgesia following cesarean delivery is intrathecal morphine, which is not devoid of complications namely postoperative nausea and vomiting. We evaluated the antiemetic effect of intravenous dexamethasone combined with intrathecal atropine after cesarean delivery under spinal bupivacaine plus morphine anesthesia.

Enrollment: 120 patients

Sex: Female

Ages: 20 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• females
• 18-40 years of age
• elective cesarean delivery under bupivacaine spinal anesthesia

Exclusion criteria

• renal disease
• preeclampsia
• liver disease
• cardiac disease
• Coagulopathy
• chronic cough
• nausea
• vomiting
• patient refusal

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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120 participants in 3 patient groups

Atropine group

Active Comparator group

Description:

Atropine group (A): Patients received intrathecal heavy Marcaine, 2 ml, 0.5% plus 300 µg morphine and 100 µg atropine (0.5ml), and intravenous injection of 2ml normal saline.

Treatment:

Drug: Intrathecal atropine

Dexamethasone group

Active Comparator group

Description:

Dexamethasone group (D): Patients received intrathecal heavy Marcaine 2 ml, 0.5% plus 300 µg morphine (0.5ml), and intravenous 8 mg dexamethasone (2ml).

Treatment:

Drug: dexamethasone

Dexamethasone and Atropine group

Active Comparator group

Description:

Dexamethasone and Atropine group (DA): Patients received intrathecally as group A, plus intravenous injection of 2 ml, dexamethasone 8 mg. Postoperative follow-up of both nausea and vomiting was done over 24 hours postoperative.

Treatment:

Drug: Intrathecal atropine

Drug: dexamethasone