Intrathecal Morphine for Thoracoscopic Surgery

Çukurova University

Status and phase: Completed; Phase 4

Conditions: Postoperative Pain

Treatments: Drug: Morphine

Study type: Interventional

Funder types: Other

Identifiers

NCT05588336

ITM1

Details and patient eligibility

About

Thoracic surgery is one of the surgeries where postoperative pain is intense. In this study, the investigators aimed to compare the efficacy of two different intrathecal morphine doses administered for postoperative analgesia according to patients' ideal body weight.

Full description

Patients who underwent video-assisted thoracic surgery were divided into two groups: 10 mcg/kg and 7 mcg/kg intrathecal morphine for postoperative analgesia. Intraoperative and postoperative hemodynamic variables, postoperative morphine consumption, postoperative pain scores, side effects and additional analgesic requiretment were recorded.

Enrollment: 46 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• > 18 years old
• ASA class I and II
• Video-assisted thoracoscopic surgery

Exclusion criteria

• < 18 years old
• ASA class > II
• Serious hepatic, cardiac, renal, metabolic, endocrine diseases
• Coagulation disfunction
• Allergy to any of the study drugs
• Pneumonectomy
• Infection in the lumbar region

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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46 participants in 2 patient groups

10 mcg/kg intrathecal morphine

Active Comparator group

Description:

For postoperative analgesia, before surgical incision, 10 mcg/ideal body weight morphine HCl (in 2 ml volume) was administered intrathecally at L4-5 interspace in the lateral decubitis position.

Treatment:

Drug: Morphine

7 mcg/kg intrathecal morphine

Active Comparator group

Description:

For postoperative analgesia, before surgical incision 7 mcg/ideal body weight morphine HCl (in 2 ml volume) was administered intrathecally at L4-5 interspace in the lateral decubitis position.

Treatment:

Drug: Morphine