Intrathecal Morphine in Knee Arthroplasty

University College Hospital Galway

Status: Completed

Conditions: Arthroplasty, Replacement, Knee; Pain, Postoperative

Treatments: Drug: intra thecal morphine

Study type: Interventional

Funder types: Other

Identifiers

NCT00695045

0001

Details and patient eligibility

About

This study is designed to explore the efficacy lower doses of intra-spinal morphine for pain relief and side effect profiles of same in the setting of Total Knee Replacement.We hypothesized that a dose greater than that used in Total Hip Replacement was needed and wished to find a dose which was effective but had a low side effect profile.

Enrollment: 60 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients for elective total knee arthroplasty

Exclusion criteria

• No contraindication to spinal
• No allergy to morphine, rescue analgesia or anti-emesis treatment.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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60 participants in 3 patient groups

1

Experimental group

Description:

patients in this group got 100mcg of intrathecal morphine.

Treatment:

Drug: intra thecal morphine

Drug: intra thecal morphine

Drug: intra thecal morphine

2

Experimental group

Description:

patients in this group got 200 mcg intrathecal morphine

Treatment:

Drug: intra thecal morphine

Drug: intra thecal morphine

Drug: intra thecal morphine

3

Experimental group

Description:

patients in this group given 300 mcg intrathecal morphine.

Treatment:

Drug: intra thecal morphine

Drug: intra thecal morphine

Drug: intra thecal morphine