Intrathecal Radioimmunotherapy, Radiation Therapy, and Chemotherapy After Surgery in Treating Patients With Medulloblastoma

Memorial Sloan Kettering Cancer Center (MSK)

Status

Completed

Conditions

Brain and Central Nervous System Tumors

Treatments

Drug: cisplatin

Radiation: iodine I 131 monoclonal antibody 3F8

Radiation: radiation therapy

Procedure: adjuvant therapy

Drug: lomustine

Drug: vincristine sulfate

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT00058370

MSKCC-02088

02-088

Details and patient eligibility

About

RATIONALE: Radioimmunotherapy uses radiolabeled monoclonal antibodies to locate tumor cells and deliver radioactive tumor-killing substances to them without harming normal cells. Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining intrathecal radioimmunotherapy and radiation therapy with combination chemotherapy may kill any tumor cells remaining after surgery.

PURPOSE: Phase II trial to study the effectiveness of combining intrathecal radioimmunotherapy and radiation therapy with combination chemotherapy in treating patients who have undergone surgery for medulloblastoma.

Full description

OBJECTIVES:

Determine the feasibility of combining post-operative intrathecal radioimmunotherapy, craniospinal radiotherapy with intensity-modulated radiotherapy boost, and chemotherapy in patients with standard-risk medulloblastoma.
Determine whether this regimen can maintain or exceed the current progression-free survival rate while decreasing long-term serious morbidity in these patients.
Determine the long-term morbidities, most specifically neuropsychological, neuroendocrine, audiometric, and growth outcomes, in patients treated with this regimen.

OUTLINE:

Radioimmunotherapy: Patients receive intrathecal iodine I 131 monoclonal antibody 3F8 on days 1 and 8.
Radiotherapy: Beginning as soon as possible after radioimmunotherapy, patients undergo external-beam and intensity-modulated radiotherapy 5 days a week for 6 weeks.
Chemotherapy: Patients receive vincristine IV once weekly for 8 weeks concurrently with radiotherapy. Beginning about 6 weeks after completion of radiotherapy (4 weeks after vincristine), patients receive cisplatin IV over 6 hours and oral lomustine on day 0 and vincristine IV on days 0, 7, and 14. Treatment repeats every 6 weeks for up to 8 courses in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed periodically.

PROJECTED ACCRUAL: A total of 6-20 patients will be accrued for this study within 3.2 years.

Enrollment

6 patients

Sex

All

Ages

3+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients must have histologic proof of medulloblastoma reviewed by the Department of Pathology at the Memorial Sloan-Kettering Cancer Center.
Patients must begin study prescribed therapy within 42 days of neurosurgical resection of the tumor
Age ≥ 3-years-old. Post-operative head MRI must confirm ≤ 1.5 cm2 of residual tumor is present.
Head and spine MRI and lumbar CSF cytology must not show any definitive evidence of leptomeningeal dissemination (Chang stage M-0).
Examinations evaluating extra-neural sites will not be mandated, but any performed for clinical indications must be free of metastatic disease.
No prior RT or chemotherapy for the medulloblastoma is permitted Patients must have adequate CSF flow (defined as lack of compartmentalization) on an 111-Indium DTPA flow study.
Patients must have adequate organ function as defined by:
Hepatic: total bilirubin < 2.0 mg/dl, AST < 3 x the upper limit of normal.
Renal: Calculated creatinine clearance or nuclear GFR ≥ 70 ml/min/1.73 m^2.
The patient, or for minors, a parent or legal guardian, must give informed written consent indicating they are aware of the investigational nature of this study.

Exclusion criteria

Unable to start study prescribed therapy within 42 days of neurosurgical resection of the tumor
Age less than 3 years > 1.5 cm2 residual tumor on post-operative head MRI
Evidence of leptomeningeal dissemination on head or spine MRI or CSF cytology positivity
Evidence of extra-neural metastases
Prior radiation therapy or chemotherapy for the medulloblastoma
Inadequate CSF flow on 111-Indium DTPA flow study Patients with signs or symptoms suggestive of increased intracranial pressure (headache, emesis, ocular paresis) will not be eligible until they are cleared by neurology and/or neurosurgery.
Pregnancy
Total bilirubin ≥ 2.0 mg/dl
AST ≥ 3 x the upper limit of normal
Creatinine clearance and GFR < 70 ml/min/1.73 m^2

Trial design

Primary purpose

Treatment

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

6 participants in 1 patient group

histologic proof of medulloblastoma

Experimental group

Description:

This is a single-arm study of post-operative radioimmunotherapy (intrathecal 131-I-3F8), reduced-dose craniospinal radiation therapy (1800 cGy), primary site boost (to 5400 cGy) via IMRT and standard chemotherapy.