Intratumoral Budding (ITB) in Preoperative Biopsies of Colon and Rectal Cancer

Insel Gruppe AG, University Hospital Bern

Status: Active, not recruiting

Conditions: CRC

Study type: Observational

Funder types: Other

Identifiers

NCT03336658

393/14

Details and patient eligibility

About

All the preoperative biopsies of patients suffering colorectal cancer (CRC) will be immunohistochemically stained with a pancytokeratin marker to detect Tumor buds. then, the intratumoral buds (ITB) in the densest Region of Tumor buds, namely the "hot spot" will be counted. Subsequently, the probability of N stage (lymphnodes), M stage (metastases) and disease free survival (DFS) will be calculated based on an existing logistic Regression model already developed by our previous retrospective work. Additionally, a Standardisation of ITB using a well- established Software will develop an algorithm which will help to eliminate inter- observer variability of Tumor budding Counts.

Enrollment: 150 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with newly diagnosed stages I and IV colorectal cancer (CRC)
• Age ≥ 18 years
• Written Informed Consent

Exclusion criteria

• No consent
• < 18 years