Intrauterine Autologous PRP Infusion Compared to HRT for Enhancing Endometrial Thickness in Patients Undergoing ICSI

Ain Shams University

Status and phase: Unknown; Phase 2; Phase 1

Conditions: Infertility

Treatments: Biological: platlet rich plasma

Study type: Interventional

Funder types: Other

Identifiers

NCT02660294

PRP-IVF

Details and patient eligibility

About

Successful embryo implantation needs an optimum embryonic development with a receptive endometrium. Endometrial thickness is an independant factor for endometrial receiptivity. The aim of that trial is to assess the benefecial effect of platelt rich plasma in copmarison with standard hormonal therapy.

Full description

This is a single blinded randomized trial comparing the effect of of platlet rich plasma versus hormonal therapy on endometrial thickness and consequently endometrial receptivity. The primary endpoint of this trial is clinical pregnancy rate.

Enrollment: 30 estimated patients

Sex: Female

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patients undergoing ICSI
• endometrial thickness less than 7 mm on early follicular phase

Exclusion criteria

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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30 participants in 2 patient groups

Platlet rich plasma

Experimental group

Description:

For those with endometrial thickness less than 7 mm intrauterine injection of platlet rich plasma (PRP) for enhancing endometrial thickness and receptivity

Treatment:

Biological: platlet rich plasma

Hormone replacement therapy

No Intervention group

Description:

Oral intake of estradiol valerate for those with endometrial thickness less than 7 mm will improve endometrial receptivity