Intrauterine Hyaluronic Acid Gel for Prevention of Intrauterine Adhesions

Barzilai Medical Center

Status: Unknown

Conditions: Prevenetion of Intrauterine Adhesions by Hyaluronic Acid Gel

Treatments: Drug: Intrauterine injection of hyaluronic acid

Study type: Interventional

Funder types: Other

Identifiers

NCT04975373

0002-21

Details and patient eligibility

About

Women undergoing operative hysteroscopy for removal of retained placenta after delivery will be randomized into two groups.

1. study group - immediately after operative hysteroscopy 5 ml hyaluronic acid gel will be injected into uterine cavity
2. control group - no injection

4-8 weeks after operative hysteroscopy, participants will undergo diagnostic hysteroscopy with no anesthesia , as a part of routine evaluation after removal of retained placenta in Israel.

during diagnostic hysteroscopy the uterine cavity will be evaluated and the presence of adhesions and severity of adhesions will be recorded.

Enrollment: 160 estimated patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women undergoing hysteroscopic removal of retained placenta after delivery

Exclusion criteria

• Known adverse reaction or allergy to hyaluronic acid

History of intrauterine adhesions

Acute pelvic inflammatory disease

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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160 participants in 2 patient groups

study group

Other group

Description:

study group women in this group will receive intrauterine hyaluronic acid injection after operative hysteroscopy

Treatment:

Drug: Intrauterine injection of hyaluronic acid

control group

No Intervention group

Description:

women will not receive hyaluronic acid after operative hysteroscopy