Intrauterine Injection of Human Chorionic Gonadotropin Before Embryo Transfer in Women With Previous IVF Failure

Mansoura University

Status and phase: Unknown; Phase 4

Conditions: Infertility; Invitro Fertilization

Treatments: Drug: Human Chorionic Gonadotropin (HCG)

Study type: Interventional

Funder types: Other

Identifiers

NCT02329197

H005

Details and patient eligibility

About

Women with history of previous IVF cycle failure will be subjected to a fresh IVF cycle. At the time they will be undergoing embryo transfer, 50 IU of human chorionic gonadotropins diluted in 0.025ml of tissue culture media will be injected intrauterine by embryo transfer catheter 10 minutes before embryo transfer procedure.

Full description

Infertile women with history of previous IVF cycle failure will be subjected top a fresh IVF cycle. Following controlled ovarian hyperstimulation, ovum pick up and at the time they will be undergoing embryo transfer, 50 IU of human chorionic gonadotropins diluted in 0.025ml of tissue culture media will be injected intrauterine by embryo transfer catheter 10 minutes before embryo transfer procedure.

Enrollment: 380 estimated patients

Sex: Female

Ages: 19 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• women with previous IVF failure undergoing fresh IVF cycle

Exclusion criteria

• women with hydrosalpinges women with intrauterine lesion like submucous fibroid or polyps

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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380 participants in 2 patient groups

Group A

Experimental group

Description:

women undergoing IVF treatment will be subjected for intrauterine injection of 10 IU of human chorionic gonadotropin (HCG) (diluted in 0.025ml of tissue culture), 10 minutes before embryo transfer procedure.

Treatment:

Drug: Human Chorionic Gonadotropin (HCG)

Group B

No Intervention group

Description:

women undergoing IVF treatment will embryo transfer procedure performed in the standard way without intrauterine injection of HCG.