Intravascular Laser Irradiation of Blood Use in Poor Ovarian Responders

Kaohsiung Veterans General Hospital

Status: Active, not recruiting

Conditions: Unrecognized Condition

Treatments: Other: Intravascular laser irradiation of blood

Study type: Interventional

Funder types: Other

Identifiers

NCT05873075

KSVGH23-CT3-20

Details and patient eligibility

About

The aim of this study was to investigate the effects of intravascular laser irradiation of blood on outcomes of in vitro fertilization cycles in poor ovarian responders.

Full description

Intravascular laser irradiation of blood (ILIB) with He-Ne laser (632.8nm) has been applied on many organs and on the hematologic and immunologic system. Quite a number of both animal and human experiments have demonstrated that ILIB has a wide range of effects, including biostimulation, analgesia, antiallergic effects, immunomodulation, vasodilatation, antihypoxic, anti-oxidant, anti-aging and anti-inflammatory effects.

Poor ovarian responders (PORs) defined as poor or no response to ovarian stimulation had poor prognosis in assisted artificial technique (ART), which is a great challenge in in vitro fertilization (IVF) cycles. Previous studies showed that treatment with anti-oxidants could improve the outcomes of the poor ovarian responders; however, the effect is limited. Since ILIB has anti-aging, anti-oxidant and anti-inflammatory effects, the investigators hypothesize that ILIB may improve ovarian function and oocyte quality in PORs. Therefore, the investigators attempt to explore the effects of ILIB on the IVF outcomes in women with poor ovarian response.

Enrollment: 60 estimated patients

Sex: Female

Ages: 30 to 44 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women who undergoes IVF cycles
• BMI:18-30 kg/m2
• Diminished ovarian reserve (AFC<5, AMH<1.2 ng/ml)

Exclusion criteria

• Primary ovarian insufficiency
• Congenital uterine anomaly
• Severe intrauterine adhesion
• Severe male factor (azoospermia)
• Chromosome anomaly
• Malignancy
• Donor cycles

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

Study group

Experimental group

Description:

Patients received intravascular laser irradiation of blood for 20 days before IVF cycles

Treatment:

Other: Intravascular laser irradiation of blood

Control

No Intervention group

Description:

No intervention before IVF cycles