Intravascular Radiofrequency Ablation of Sympathetic Nerves for the Treatment of Hepatocellular Carcinoma

Southeast University

Status: Enrolling

Conditions: Hepatocellular Carcinoma

Treatments: Procedure: endovascular radiofrequency ablation and desympathetic nerve surgery

Study type: Interventional

Funder types: Other

Identifiers

NCT06694636

2024ZDSYLL167-P01

Details and patient eligibility

About

Patients who met the inclusion criteria were treated with endovascular radiofrequency ablation and desympathetic nerve surgery. After enrollment, endovascular radiofrequency ablation and desympathetic surgery were performed. After radiofrequency ablation, the safety and efficacy of follow-up treatment will be carried out every 1 month or so, including blood routine, liver and kidney function, tumor indicators, abdominal CT/magnetic resonance, etc.

Enrollment: 5 estimated patients

Sex: All

Ages: 25 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinically or pathologically confirmed hepatocellular carcinoma (HCC)
• Locally progressed or distant metastatic unresectable advanced HCC
• Progressed after second-line therapy
• Agree to participate in the study and sign the informed consent form

Exclusion criteria

• Not suitable for ablation surgery
• Pregnant, lactating and planning to become pregnant
• Orthostatic hypotension
• Mixed liver cancer
• Intestinal obstruction
• Obvious bleeding tendencies and hematologic diseases
• Acute or severe systemic infection;
• Stroke or transient ischemic attack (TIA) within two weeks;
• Acute coronary syndrome within two weeks;
• Evaluated to be not suitable for this trial by investigators

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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5 participants in 1 patient group

Intravascular Radiofrequency Ablation of Sympathetic Nerves Group

Experimental group

Description:

Enrolled patients will receive Intravascular Radiofrequency Ablation of Sympathetic Nerves for the Treatment of Hepatocellular Carcinoma

Treatment:

Procedure: endovascular radiofrequency ablation and desympathetic nerve surgery