Intravenous Administration of Vitamin B Complex Improves Renal Recovery in Patients with AKI (VIBAKI)

Caja Nacional de Salud

Status and phase: Completed; Phase 4

Conditions: Acute Kidney Injury

Treatments: Other: STOP AKI protocol; Drug: Vitamin B Complex

Study type: Interventional

Funder types: Other

Identifiers

NCT04893733

VBCNS

Details and patient eligibility

About

Animal and human studies have shown that the administration of vitamin B3 (niacin) improves renal ischemia; helping to recover from acute kidney injury (AKI) more effectively; Therefore, its use in patients with AKI could improve short-term outcomes: accelerating the recovery of renal function, reducing the days of hospital stay and costs; as well as reducing the incidence of chronic kidney disease (CKD) or progression of CKD after an episode of AKI.

Our main objective is to determine the usefulness of the administration of vitamin B complex as a treatment for established acute kidney injury and its effect on short and long-term outcomes.

Enrollment: 260 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients over 18 years of age who meet modified KDIGO criteria for Acute Kidney Injury, based on serum creatinine or urinary volume criteria.

Exclusion criteria

• Patient under 18 years of age
• Patients with stage G5 chronic kidney disease
• Patients with chronic kidney replacement therapy.
• Pregnant women
• Transplant patients

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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260 participants in 1 patient group

Vitamin B complex

Experimental group

Description:

Randomized patients with AKI to this arm will received during 5 consecutive days IV Vitamin B complex each 12 hours.

Treatment:

Drug: Vitamin B Complex

Other: STOP AKI protocol