Intravenous Ascorbic Acid Administration in Hysterectomy

Shahid Beheshti University

Status and phase: Completed; Phase 3

Conditions: Abdominal Hysterectomy

Treatments: Drug: vitamin C

Study type: Interventional

Funder types: Other

Identifiers

NCT03965637

17912

Details and patient eligibility

About

vitamin C or ascorbic acid has known role in tissue repair. due to it's properties(water_soluble), vitamin c is not stored in the body and when depleted, the bleeding tendency will increase due to dysfunctional connective tissues production in vessel wall and it has some important functions in platelets.

Full description

In this randomized clinical trial, 1000 mg vitamin C will administrate intravenously a day before surgery and during surgery in patients who undergo abdominal hysterectomy.

Enrollment: 80 patients

Sex: Female

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• To be 18 years and older
• No smoking
• No history of bleeding disorder
• No history of favism
• No history of uterus, ovary, cervical cancer

Exclusion criteria

• Need to injection of vasopressor drugs
• Surgeon disagreement

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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80 participants in 2 patient groups

vitamin C

Experimental group

Description:

Intervention patients will be received double dose of Ascorbic acid via intravenous injection

Treatment:

Drug: vitamin C

Control

No Intervention group

Description:

Control patients will not be received any intervention