Intravenous Dexamethasone on Postoperative Pain and Complications in Jaw Surgery (DXM-PAIN)

Selcuk University

Status and phase: Completed; Phase 4

Conditions: Cysts Dental; General Anesthesia; Tooth Extraction Status Nos

Treatments: Drug: Dexamethasone

Study type: Interventional

Funder types: Other

Identifiers

NCT06787196

F003

Details and patient eligibility

About

This study aims to evaluate the effect of single-dose intravenous dexamethasone on postoperative pain and other complications in compacted tooth and cyst enucleation procedures performed under general anesthesia.

Full description

During surgery, patients were carefully monitored with standard equipment to track oxygen levels (SpO2), heart activity (ECG), blood pressure, and carbon dioxide levels. General anesthesia was started with medications like thiopental, rocuronium, and fentanyl, and maintained with a mix of oxygen, air, sevoflurane, and remifentanil. Patients were intubated with appropriate tubes, and the surgical team applied a local anesthetic (Articaine with Epinephrine) to the area before starting the procedure. After the surgery, patients were given dexamethasone (DXM) and pantoprazole intravenously, then safely extubated and sent to recovery. All patients were discharged on the same day.

Postoperative recovery was assessed using pain scores (VAS) and physical evaluations. Pain levels were categorized as mild, moderate, or severe, and an analgesic was provided if the score exceeded 3. Facial swelling was measured by comparing pre- and post-surgery facial landmarks, with swelling classified into grades based on the percentage of change. Mouth opening was evaluated with a caliper to check for trismus (jaw stiffness), with results grouped into normal, mild, moderate, or severe grades depending on the degree of restriction. Follow-ups were conducted by an independent clinician on postoperative days 1, 2, and 7.

Enrollment: 60 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA physical status I-II
• underwent split-mouth surgery

Exclusion criteria

• Patients undergoing corticosteroid therapy

Trial design

Primary purpose: Supportive Care

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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60 participants in 1 patient group

Dexamethasone

Experimental group

Description:

At the end of the procedure, patients received a single IV dose of Dexamethasone (0.1 mg/kg) before being extubated.

Treatment:

Drug: Dexamethasone