Intravenous Ibuprofen Postoperative Analgesia After Abdominal Hysterectomy

Menoufia University

Status and phase: Active, not recruiting; Phase 2

Conditions: Post Operative Analgesia

Treatments: Drug: Ibuprofen

Study type: Interventional

Funder types: Other

Identifiers

NCT05750264

2/2023 ANET10-1

Details and patient eligibility

About

The current research is designed to investigate the analgesic efficacy of intravenous ibuprofen on the postoperative analgesic requirements, pain intensity and other recovery parameters.

Full description

The patients will be given general anaesthesia. Anaesthesia will be induced by propofol 1-2 mg/kg, and fentanyl 1-2 µg/kg. Endotracheal intubation will be facilitated by atracurium 0.5 mg/kg. Anaesthesia will be maintained by isoflurane in oxygen - air mixture. Transversus abdominis plane block will be performed at the end of the operation. A postoperative analgesic regimen according to group allocation will be started.

Enrollment: 152 patients

Sex: Female

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of anaesthesiologists physical status I to III.
• Open abdominal hysterectomy operations

Exclusion criteria

• History of gastrointestinal bleeding.
• History of intracranial haemorrhage.
• Pregnancy and lactation.
• Taking angiotensin converting enzyme(ACE) inhibitors or anticoagulation drugs.
• Asthmatic, hepatic,renal or heart failure.
• Abnormal platelet count.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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152 participants in 2 patient groups

ibuprofen group

Active Comparator group

Description:

intravenous ibuprofen 800mg in 200 ml normal saline+IV paracetamol 1000mg+Transversus abdominis plane block

Treatment:

Drug: Ibuprofen

Control group

No Intervention group

Description:

200 ml normal saline+IV paracetamol1000mg+Transversus abdominis plane block