Intravenous Immunoglobin Transfusion in Preterm Infants With Encephalopathy of Prematurity

Army Medical University of People's Liberation Army

Status: Enrolling

Conditions: Preterm Infants

Treatments: Drug: non-human gamma globulin; Drug: human gamma globulin

Study type: Interventional

Funder types: Other

Identifiers

NCT02822027

IVIG for encephalopathy

Details and patient eligibility

About

Infection and inflammation is related to increased encephalopathy of prematurities.

Full description

Animal studies have verified intravenous immunoglobin can reduce brain injury. However, no studies in preterm infants were reported.

Enrollment: 20 estimated patients

Sex: All

Ages: Under 6 hours old

Volunteers: No Healthy Volunteers

Inclusion criteria

• preterm infants with encephalopathy

Exclusion criteria

• refuse the participate in the trial

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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20 participants in 2 patient groups

human gamma globulin

Experimental group

Description:

human gamma globulin for infants with encephalopathy of prematurities

Treatment:

Drug: human gamma globulin

Drug: non-human gamma globulin

non-human gamma globulin

Active Comparator group

Description:

non-human gamma globulin for infants with encephalopathy of prematurities

Treatment:

Drug: human gamma globulin

Drug: non-human gamma globulin