Intravenous Infusion of Lidocaine in Colonoscopy

Shandong University

Status and phase: Unknown; Phase 4

Conditions: Sedation

Treatments: Drug: placebo; Drug: lidocaine

Study type: Interventional

Funder types: Other

Identifiers

NCT04439786

2020SDU-QILU-021

Details and patient eligibility

About

intravenous infusion of lidocaine significantly reduce fatigue and pain and improve the patients satisfaction after sedation for colonoscopy.

Full description

This study divide patients into two groups, lidocaine group one will be given lidocaine intravenously; control group will be given saline . the difference between patients fatigue and pain will be compared. and the propofol consumption, pain after infusion of propofol, patients, endoscopists and anaesthesist satifaction, the incidence of hypotenstion, hypoxia, and bradycardia will aslo be compared between the two groups.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

Inclusion Criteria: patients aged >18 years who were scheduled for colonscopy at Qilu hospital.

Exclusion Criteria:patients with ASA (American Society of Anesthesiologists) Class 4 or 5, pre-existing hypoxemia (SpO2 <90%), hypotension (systolic blood pressure <90 mm Hg), bradycardia (HR<50 beats/min), uncontrolled hypertension (SBP >170 mm Hg, diastolic blood pressure>100 mm Hg), severe renal or liver failure, pregnancy or lactation, allergy to lidocaine, atrioventricular block, epilepsy, and inability to give informed consen

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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50 participants in 2 patient groups, including a placebo group

control group

Placebo Comparator group

Description:

the control group will be given the same volume of saline as the experimental group

Treatment:

Drug: placebo

lidocaine group

Experimental group

Description:

the experimental group will be given l-1.5mg lidocaine and then 2mg/kg/h

Treatment:

Drug: lidocaine