Intravenous Insulin in Patients With Diabetes After Percutaneous Coronary Intervention (PCI)

Hospital de Clinicas de Porto Alegre

Status: Terminated

Conditions: Percutaneous Coronary Intervention; Diabetes Mellitus

Treatments: Drug: Intravenous Insulin

Study type: Interventional

Funder types: Other

Identifiers

NCT00967642

06036

Details and patient eligibility

About

The purpose of this study is to evaluate the effects of intravenous insulin/24 hours to normalize glycemia upon markers of oxidative stress (protein oxidation and total antioxidant defense) and inflammation (C-reactive protein (CRP) and sCD40L) in diabetic patients submitted to PCI with stent.

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with Diabetes Mellitus submitted to Percutaneous Coronary Intervention with Stent bare metal
• Age: 18-80 years old

Exclusion criteria

• Restenosis
• Drug elution stent
• Acute coronary syndrome at last 30 days
• Use anti inflammatory, antibiotic, vitamin E
• Inflammatory disease or oncologic

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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70 participants in 2 patient groups

standard treatment

No Intervention group

Description:

glycemia before meals and subcutaneous regular insulin if higher than 200 mg/dl

Intravenous Insulin

Other group

Description:

intravenous insulin/24h guided by glycemia (Optium, Abbott) evaluated hourly, targeting values lower than 110 mg/dl

Treatment:

Drug: Intravenous Insulin