Intravenous (IV) Saline and Exercise in Postural Tachycardia Syndrome (POTS)

Vanderbilt University Medical Center

Status: Active, not recruiting

Conditions: Postural Tachycardia Syndrome

Treatments: Drug: Saline; Other: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT01000350

090942

Details and patient eligibility

About

The investigators will test whether an intravenous infusion of saline (salt water) will improve the exercise capacity in patients with postural tachycardia syndrome (POTS).

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Meet diagnostic criteria of Postural Tachycardia Syndrome (POTS) 28
• Age between 18-65 years
• Male and female are eligible (although the majority of POTS patients are female).
• Able and willing to provide informed consent

Exclusion criteria

• Presence of medical conditions that can explain postural tachycardia (e.g., acute dehydration, medications)
• Pregnancy
• Other factors which in the investigator's opinion would prevent the subject from completing the protocol.
• Patients who are bedridden or chair-ridden

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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40 participants in 2 patient groups, including a placebo group

Exercise Post Saline

Experimental group

Description:

Saline infusion 1L hours before exercise test

Treatment:

Drug: Saline

Placebo

Placebo Comparator group

Description:

Placebo given prior to exercise test

Treatment:

Other: Placebo