Intravenous Lidocaine in Open Lung Resection Surgery

Saint-Joseph University

Status and phase: Completed; Phase 4

Conditions: Lidocaine; Pain, Postoperative

Treatments: Drug: Normal Saline; Drug: Lidocaine Iv

Study type: Interventional

Funder types: Other

Identifiers

NCT04480281

CEHDF 972

Details and patient eligibility

About

Management of postoperative pain in 2020 remains a challenge for anesthesiologists in the perioperative period. Lidocaine is an amide local anesthetic, it is one of the oldest adjuvant analgesics and is known to possess analgesic, anti-hyperalgesic and anti-inflammatory properties. Lidocaine is proven to be as effective as epidural analgesia in colorectal surgery.

However, no study has evaluated the effect of a continuous lidocaine infusion for open lung resection in the post-operative period. The present study aims to evaluate the influence of IV lidocaine given during and 24 hours after surgery, on pain scores, opioid consumption, and possible benefits on patient outcome via the opioid-sparing effect in open thoracic surgery

Enrollment: 60 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American society of anesthesiologists (ASA) scores of I, II or III.
• Left or right posterolateral thoracotomy with postoperative monitoring in the intensive care unit (ICU) for at least 24 hours (h).

Exclusion criteria

• patient's refusal to participate
• ASA score of IV or higher
• severe hepatic or renal insufficiency
• allergy to lidocaine, morphine or NSAIDs
• cardiac arrhythmias or
• epilepsy,
• delayed extubation for more than 2 h postoperatively
• urgent surgery

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups, including a placebo group

Lidocaine Group

Active Comparator group

Description:

Bolus of lidocaine 1% 1.5mg/kg at the induction of general anesthesia followed by a continuous infusion of lidocaine 1% 2mg/kg/h just before surgical incision and continued until 24h after the surgery

Treatment:

Drug: Lidocaine Iv

Placebo Group

Placebo Comparator group

Description:

Equal bolus volume of normal saline solution at induction, and then a continuous infusion started before surgical incision and maintained up until 24h postoperatively

Treatment:

Drug: Normal Saline