Intravenous Metoprolol Versus Intravenous Amiodarone in the Prevention of Atrial Fibrillation After Cardiac Surgery

Kuopio University Hospital

Status and phase: Completed; Phase 4

Conditions: Cardiac Surgery; Atrial Fibrillation

Treatments: Drug: metoprolol, amiodarone

Study type: Interventional

Funder types: Other

Identifiers

NCT00784316

KUH5204005

Details and patient eligibility

About

The aim of the study is to test the efficiency of intravenous administration of metoprolol versus intravenous administration of amiodarone in the prevention of atrial fibrillation after cardiac surgery.

Enrollment: 316 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• elective CABG and aortic valve patients in cardiac surgery,
• previous use of betablocker therapy

Exclusion criteria

• previous atrial fibrillation or flutter,
• thyroid disease,
• uncontrolled heart failure,
• II or III degree atrioventricular block

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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316 participants in 2 patient groups

metoprolol

Active Comparator group

Treatment:

Drug: metoprolol, amiodarone

amiodarone

Active Comparator group

Treatment:

Drug: metoprolol, amiodarone