Intravenous Pantoloc In Aspirin-Induced Ulcer Bleeding

The Chinese University of Hong Kong logo

The Chinese University of Hong Kong

Status

Completed

Conditions

Cerebrovascular Disorders
Cardiovascular Disease

Treatments

Drug: Aspirin and Pantoloc

Study type

Interventional

Funder types

Other

Identifiers

NCT00153725
PPA Study

Details and patient eligibility

About

The aim of the study is to investigate whether intravenous infusion of pantoprazole (Pantoloc) is effective in preventing recurrent bleeding in patients who present with acute ulcer bleeding and continue to use aspirin

Full description

Aspirin is an effective treatment for acute stroke and heart attack. However, aspirin also induces ulcer and provokes acute ulcer bleeding. Thus, aspirin is often withheld in acute ulcer bleeding but this precipitate recurrent stroke or heart attack. We previously showed that intravenous infusion of a potent acid suppressant substantially reduced the incidence of recurrent ulcer bleeding in patients who withheld aspirin. The aim of this study is to investigate whether intravenous infusion of an acid suppressant (Pantoprazole) is effective in preventing recurrent ulcer bleeding with continuous use of aspirin.

Sex

All

Ages

18 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

* Patients received daily anti-platelet therapy for vascular prophylaxis before admission and will continue need to do so * Patinets with bleeding peptic ulcers;ulcer actively bleeding or with SRH (Forrest I, IIa and IIb ulcers) * Endoscopic haemostasis achieved

Exclusion criteria

* Presence of ulcer complication precluding endoscopic treatment such as gastric outlet obstruction or ulcer perforation mandating surgical intervention. * Concomitant use of anticoagulant, NSAIDs or steroid * Pending to undergo cardiac interventions that need double anti-platelet agent * Pregnancy * Terminal illness, or cancer

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

Trial contacts and locations

3

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Data sourced from clinicaltrials.gov

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