Intravenous Subdissociative-dose Ketamine Versus Morphine for Prehospital Analgesia (KETAMORPH)

Nantes University Hospital (NUH)

Status and phase

Terminated

Phase 3

Conditions

Pain Management

Treatments

Drug: Ketamine

Drug: Morphine

Study type

Interventional

Funder types

Other

Identifiers

NCT03236805

RC17_0082

Details and patient eligibility

About

This is a prospective, randomized, single-blind trial evaluating prehospital patients experiencing moderate to severe acute pain, defined as a numeric rating scale score greater than or equal to 5. Patients will be randomized to receive ketamine at or morphine by intravenous push.

Full description

This study is designed to evaluate if ketamine alone is non inferior to morphine alone for prehospital analgesia. Numeric rating scale pain scores will be compared between recipients of ketamine and recipients of morphine at 15, 30, 45 and 60 min post first injection and at hospital admission.

Enrollment

285 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

older than 18 years old
prehospital moderate to severe acute pain, defined as a numeric rating scale score greater than or equal to 5

Exclusion criteria

unstable vital signs (systolic blood pressure <90 or >200 mm Hg, pulse rate <50 or >150 beats/min, and respiration rate <10 or >30 breaths/min)
pregnancy
breast-feeding
altered mental status
unable to give numeric rating scale scores
allergy to morphine or ketamine
acute pulmonary edema
acute coronary syndrome
renal or hepatic insufficiency
patient who received morphine for the same acute pain
acute psychiatric illness