Intravitreal Ranibizumab Treatment of Central Serous Chorioretinopathy

Vitreous -Retina- Macula Consultants of New York

Status and phase

Completed

Phase 1

Conditions

Central Serous Chorioretinopathy

Treatments

Drug: rhuFab V2 [ranibizumab] ( Lucentis )

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT00403325

FVF3850S

Details and patient eligibility

About

The purpose of this study is to examine the effects of Lucentis for active Central Serous Chorioretinopathy.

Full description

This is an open-label, Phase I study of intravitreally administered ranibizumab in subjects with unresolving CSC and subfoveal fluid. Patients will be evaluated at baseline with ophthalmic examination, fluorescein angiography, optical coherence tomography, and color photography. Subjects will receive open-label intravitreal injections of 0.5 mg ranibizumab administered every 28 days (± 2 days) for 3 injections. Thereafter they are to be evaluated every month until month 12. Treatment will be administered to patients if there is presence of active leakage as determined by fluorescein angiography or persistence presence of sub retinal fluid upon OCT examination at that monthly visit.

Enrollment

9 patients

Sex

All

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

A history of persistent central serous chorioretinopathy present for at least 3 months Best-corrected visual acuity (BCVA) of 20/40 (73 letters on the ETDRS chart) to light perception as measured by ETDRS protocol refraction.
No signs of choroidal neovascularization
Documented subfoveal fluid by OCT
Active leak associated with the subfoveal fluid
The ability and willingness to provide written informed consent

Exclusion criteria

Prior treatment with laser or PDT
Have uncontrolled hypertension
Have a history of thromboembolic events including stroke, transient ischemic attacks, and myocardial infarction
Have use of or need for continued anticoagulation therapy, except aspirin 325 mg/day.
Are receiving or require chronic concomitant therapy with systemic (> 5 mg) or topical ocular corticosteroids. Chronic concomitant therapy is defined as multiple doses taken daily for 14 or more consecutive days at any time within 6 months prior to screening
Previously vitrectomized eyes.
Had allergic reactions to fluorescein dye or lack of venous access.
Any other additional ocular diseases which could irreversibly compromise the visual acuity of the study eye including amblyopia, anterior ischemic optic neuropathy (AION), age related macular degeneration (AMD), retinal detachment, severe cataracts, etc.
An anticipated need for ocular surgery during the duration of the trial.
Within 1 month prior to screening, have had intra ocular surgeries (including cataract surgery) in the study eye.
Intravitreal triamcinolone or bevacizumab in the previous 2 months
Uncontrolled glaucoma (IOP > 24 mmHg) on greater than 3 medications.
Within 1 month prior to screening had YAG laser capsulotomy in the study eye
Have received any other systemic experimental drug within 12 weeks prior to enrollment.
Rubeosis iridis or neovascular glaucoma
Any untreated rhegmatogenous retinal detachment.
A visual acuity of worse than 20/400 in the fellow eye.
Unwilling or unable to follow or comply with all study related procedures.