Intravoxel Incoherent Motion (IVIM) Magnetic Resonance Imaging in Multiple Sclerosis

The Chinese University of Hong Kong

Status: Active, not recruiting

Conditions: Multiple Sclerosis

Treatments: Other: Diffusion-weighted magnetic resonance imaging

Study type: Interventional

Funder types: Other

Identifiers

NCT05391906

TiffanySo

Details and patient eligibility

About

Intravoxel incoherent motion (IVIM) is technique based on diffusion-weighted imaging (DWI). In this study, the investigators evaluate the use of IVIM in patients with Multiple Sclerosis.

Full description

Intravoxel incoherent motion (IVIM) is technique based on diffusion-weighted imaging (DWI), it is achieved through an MRI acquisition with multiple small b value to extract perfusion data. It has been shown to be a promising technique in evaluation of many brain conditions. This study seeks to assess intravoxel incoherent motion (IVIM) parameters in characterizing plaques and specific tissues in multiple sclerosis.

Enrollment: 50 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Patients who are 18 years or older.
2. Relapsing-remitting MS diagnosed as per Macdonald criteria

Exclusion criteria

1. Contraindication to MRI. For example, metal implantation in the body, claustrophobia and pregnancy.
2. Patients who are unable to tolerate the scans without moving the head as a result of symptoms such as tremor, spasticity, involuntary movements and spasms, cognitive impairment, coughing, and shortness of breath.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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50 participants in 1 patient group

Intravoxel Incoherent Motion(IVIM) MRI

Experimental group

Description:

Intravoxel incoherent motion (IVIM) is based on diffusion-weighted imaging (DWI)

Treatment:

Other: Diffusion-weighted magnetic resonance imaging