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Introduction and Influence of Total Mesorectal Excision (TME) in the Treatment of Rectal Cancer

I

Insel Gruppe AG, University Hospital Bern

Status

Completed

Conditions

Rectal Cancer

Treatments

Procedure: total mesorectal excision
Procedure: conventional rectal surgery

Study type

Observational

Funder types

Other

Identifiers

NCT00910143
KEK 08-05-09

Details and patient eligibility

About

Total mesorectal excision (TME) is a rather new operation technique in the treatment of rectal cancer. It is known to reduce the rate of local recurrences. However, the influence on long-term survival is unclear.

Full description

Background

The TME technique for rectal cancer surgery was introduced in our department in summer 1995. TME is known to reduce the rate of local recurrences. However, its influence on long-term survival in unclear.

All patients with rectal cancer from 1993 to 2001 are reviewed. The patients charts are reviewed and the following main characteristics are retrieved: age, gender, time of operation, operation technique, tumor stage, tumor localisation, tumor size, neoadjuvant or adjuvant treatment, complications, follow-up with respect to the appearance of local recurrences and distant metastases.

Comparison of two groups of patients. Group 1: patients operated before summer 1995, that is before the introduction of TME. Group 2: patients operated after summer 1995, that is after the introduction of TME.

Objective

Study the influence of a new operation method (TME) on outcome (local recurrence, survival).

Methods

All patients with rectal cancer from 1993 to 2001 are reviewed. The patients charts are reviewed and the following main characteristics are retrieved: age, gender, time of operation, operation technique, tumor stage, tumor localisation, tumor size, neoadjuvant or adjuvant treatment, complications, follow-up with respect to the appearance of local recurrences and distant metastases.

Comparison of two groups of patients. Group 1: patients operated before summer 1995, that is before the introduction of TME. Group 2: patients operated after summer 1995, that is after the introduction of TME.

Enrollment

194 patients

Sex

All

Ages

16+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

  • adenocarcinoma of the rectum
  • 16 years and older

Trial design

194 participants in 2 patient groups

1
Description:
patients operated before summer 1995, that is before the introduction of TME
Treatment:
Procedure: conventional rectal surgery
2
Description:
patients operated after summer 1995, that is after the introduction of TME.
Treatment:
Procedure: total mesorectal excision

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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