Intubating Conditions During Propofol-remifentanil Anesthesia With Topical Lidocaine

Ajou University School of Medicine

Status: Completed

Conditions: Drug Usage

Treatments: Drug: normal saline; Drug: lidocaine

Study type: Interventional

Funder types: Other

Identifiers

NCT01489683

AJIRB-MED-CT4-11-073

Details and patient eligibility

About

When not using neuromuscular blocking agent, even at optimal dosage, target-controlled infusion (TCI) of propofol and remifentanil occasionally produce unsatisfactory intubating conditions. Therefore, the investigators evaluated that the effect of tracheal lidocaine on the intubating conditions for tracheal intubation during anesthesia induction of propofol and remifentanil TCI without neuromuscular blocking agent in day-case anesthesia.

Full description

Anesthesia was induced with propofol-remifentanil TCI with the effect-site concentration of 5μg/ml and 5ng/ml, respectively. After TCI, 3 ml of normal saline or 3 ml of 4% lidocaine was instilled to larynx and trachea, following intubation was performed.

Enrollment: 50 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA I, II patients undergoing general anesthesia for reduction of nasal bone fracture

Exclusion criteria

• bronchial asthma,
• COPD,
• hypertension,
• anticipated difficult airway

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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50 participants in 2 patient groups

control

Experimental group

Description:

3 ml of normal saline was instilled to larynx and trachea

Treatment:

Drug: lidocaine

lidocaine

Active Comparator group

Description:

3 ml of 4% lidocaine was instilled to larynx and trachea before endotracheal intubation

Treatment:

Drug: normal saline