Intubation Conditions Achieved With Rapid Co-administration of Rocuronium and Propofol Versus Classical Induction

The University of Texas System (UT)

Status and phase: Completed; Phase 4

Conditions: Anesthesia

Treatments: Drug: MTPI; Drug: Classic Induction

Study type: Interventional

Funder types: Other

Identifiers

NCT05509192

HSC-MS-22-0495

Details and patient eligibility

About

The purpose of this study is to assess and compare the conditions for tracheal intubation obtained with Modified Time Principle Induction (MTPI) and that obtained with classic induction (CI). This study will compare the efficiency of tracheal intubation with the two induction techniques, as well as evaluate for potential adverse events.

Enrollment: 154 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• BMI >30 kg/M2 or Mallampati class III or IV
• Requiring general anesthesia and endotracheal intubation

Exclusion criteria

• Acute and chronic respiratory disorders, including Chronic obstructive pulmonary disease (COPD) and asthma
• American Society of Anesthesiologists (ASA) physical status classification > III
• Emergency surgery
• Induction requiring cricoid pressure
• Patients requiring awake intubation
• Pregnant women
• Patients who require an induction dose of propofol less than 1 mg/kg
• Untreated ischemic heart disease
• Contraindication to mask ventilation
• Allergy to propofol, rocuronium, or Sugammadex
• Induction requiring succinylcholine

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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154 participants in 2 patient groups

MTPI group

Experimental group

Treatment:

Drug: MTPI

Classic Induction group

Active Comparator group

Treatment:

Drug: Classic Induction