Intubation Conditions With Atracurium After Three Minutes (CINTROI)

Assistance Publique - Hôpitaux de Paris

Status: Completed

Conditions: Obesity Female Patients Require General Anaesthesia With Intubation and Atracurium Curarization

Study type: Observational

Funder types: Other

Identifiers

NCT04808440

APHP201463

Details and patient eligibility

About

The purpose of this study is to evaluate intubation conditions with the use of atracurium after a fixed three-minute delay

Full description

The recommended dose of a non-depolarizing curare to facilitate tracheal intubation is twice the active dose 95 (the dose that reduces muscle force by 95%). At this dosage, curarization of the laryngeal adductors allowing relaxation and abduction (opening) of the vocal cords is considered certain. With atracurium, the dose for intubation is 0.5 mg.kg-1 and the time to full effect is approximately 3 minutes. With the use of newer hypnotics, there are no data evaluating the conditions for intubation after a fixed time of 3 minutes as with current anesthetic practices.

Enrollment: 100 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult female
• Patient to undergo general anesthesia with intubation for scheduled gynecological surgery
• Patient informed about the study and not opposed to it

Exclusion criteria

• Patients with severe and morbid obesity (BMI>35kg/m2)
• Pregnancy
• Patients with difficult intubation
• Allergy to atracurium and to any other drug used.
• Patient under tutorship / curatorship
• Not affiliated with social insurance
• Patient with AME