Intubation Time With Low Dose Rocuronium

Gachon University Gil Medical Center

Status: Completed

Conditions: Intubation; Difficult

Treatments: Drug: Atropine; Drug: Normal saline

Study type: Interventional

Funder types: Other

Identifiers

NCT01464489

AJIRB-MED-CT4-11-074

Details and patient eligibility

About

The investigators hypothesized that increasing the cardiac output by use of atropine in children might result in a reduction of the intubation time needed to facilitate tracheal intubation.

Full description

The investigators hypothesized that increasing the cardiac output by use of atropine in children might result in a reduction of the intubation time needed to facilitate tracheal intubation. Therefore, the purpose of this study was to determine TimeEI with a low dose of esmeron (rocuronium) (0.3 mg.kg-1) for achievement of successful tracheal intubation conditions during intravenous (i.v.) anaesthesia using propofol and alfentanil in children and to determine whether administration of i.v. atropine (atropine sulphate) (10 μg.kg-1) during anaesthesia induction reduced these times.

Enrollment: 44 patients

Sex: All

Ages: 3 to 10 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists (ASA) physical status I,
• Tonsillectomy with adenoidectomy

Exclusion criteria

• Patients with known allergy to the drugs used in this study,
• A history of reactive airway disease and asthma,
• A neuromuscular disorder, an anticipated difficult airway, and
• Crying children on arrival in the operating theatre

Trial design

44 participants in 2 patient groups

Control group

Experimental group

Description:

Anaesthesia was induced with alfentanil 10 μg.kg-1, propofol 2.5 mg.kg-1 and rocuronium 0.3 mg.kg-1.And receive normal saline for control group

Treatment:

Drug: Atropine

Atropine group

Active Comparator group

Description:

Anaesthesia was induced with alfentanil 10 μg.kg-1, propofol 2.5 mg.kg-1 and rocuronium 0.3 mg.kg-1. And receive atropine (atropine sulfate) 10 μg.kg-1 for atropine group.

Treatment:

Drug: Normal saline