Invasiveness and Chemoresistance of Cancer Stem Cells in Colon Cancer

Centre Hospitalier Universitaire de Nīmes

Status: Completed

Conditions: Colorectal Neoplasms

Treatments: Biological: Samples and follow up

Study type: Observational

Funder types: Other

Identifiers

NCT01577511

LOCAL/2011/JFB-01

2011-A01141-40 (Other Identifier)

Details and patient eligibility

About

The main objective of this study is to identify and characterize subpopulations of cells with invasive capacity in colorectal cancer from primary tumor, blood and metastatic samples.

Full description

Secondary objectives include:

• Determine the intrinsic properties essential for the dissemination and chemoresistance of these cells capable of initiating tumors
• Identify a "molecular signature" for potential invasiveness and chemoresistance of cells initiating metastases.
• Describe the evolution of patients during 24 months of follow up and correlations with observed cellular profiles.
• Enrich the tumor bank of the institution.

Enrollment: 60 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The patient must have given his/her informed and signed consent
• The patient must be insured or beneficiary of a health insurance plan
• Patient with adenocarcinoma-type colorectal cancer:
• stage III at diagnosis, surgical resection of the primary tumor proposed.
• stage IV at diagnosis, surgical resection of the primary tumor and possibly of metastases proposed.
• Stage IV who have already undergone surgical excision of the primary tumor, and for whom metastasectomy is now proposed.

Exclusion criteria

• The patient is participating in another study
• The patient is in an exclusion period determined by a previous study
• The patient is under judicial protection, under tutorship or curatorship
• The patient refuses to sign the consent
• It is impossible to correctly inform the patient
• Patients for whom surgical resection of the primary tumor is not considered as an option
• PStage IV at diagnosis, but metastasectomy is not considered as an option
• Patients with positive HIV, Hepatitis B or Hepatitis C serology

Trial design

60 participants in 1 patient group

30 Patients

Description:

Patients with operable, stage III or IV, adenocarcino-type colorectal cancer treated at the Nîmes University Hospital. Intervention: Samples and follow up

Treatment:

Biological: Samples and follow up