Inventory of Radiological and Vestibular Function in Cochlear Implant Candidates

Jessa Hospital

Status: Unknown

Conditions: Radiology; Bilateral Vestibular Deficiency; DFNA9; Hearing Loss, Sensorineural

Treatments: Diagnostic Test: video nystagmography

Study type: Observational

Funder types: Other

Identifiers

NCT04066270

JessaH-3

Details and patient eligibility

About

In 2014 radiological lesions at one or more semicircular canals (SCC) were described using CT & MR imaging in subjects presenting advanced hearing and vestibular deterioration caused by the p.P51S mutation in COCH. Similar lesions were also described in other non-genetic advanced hearing and vestibular deterioration as well. With this prospective observational study it is the purpose to inventory imaging results of candidates for cochlear implantation which are routinely performed during the preoperative work up, since these patient present severe hearing impairment at both ears. A considerable part of them might present vestibular deterioration as well. It is the purpose to detect possible presence of these SCC lesions on CT and MR in this population and the prevalence of these lesions compared to DFNA9 patients.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• must be eligible for cochlear implantation
• must be 18 years of age or older

Exclusion criteria

• <18 years of age
• not eligible to undergo vestibular tests, especially videonystagmography
• contra-indication for MR or CT

Trial design

40 participants in 2 patient groups

study group

Description:

candidates for cochlear implantation 18 years or older, who are eligible for implantation for the indication of bilateral severe hearing loss or single sided deafness. clinical audiometric and vestibular investigations, CT and MR imaging of petrous bone

Treatment:

Diagnostic Test: video nystagmography

control group

Description:

Symptomatic DFNA9 patients carrying the p.P51S mutation in COCH, presenting the radiologic semicircular canal lesion(s) on CT and/or MR. clinical audiometric and vestibular investigations, CT and MR imaging of petrous bone

Treatment:

Diagnostic Test: video nystagmography