Investigate the Effect of Ezetimibe, Simvastatin, and Omega 3- Fatty Acids on Dyslipidemia Patients: a Pharmacokinetics Based Study

Misr University for Science and Technology

Status: Unknown

Conditions: Hyperlipidemia; Mixed

Treatments: Drug: Ezetimibe 10mg

Study type: Observational

Funder types: Other

Identifiers

NCT05080140

1606YAS141008

Details and patient eligibility

About

This randomized controlled pharmacokinetic based study will be carried out on patients with both sexes and various ages, plasma triglycerides levels, clinical health disorders and using different agents for treatment of their hyperlipidemia in order to access the optimal drug therapy with best cost effectiveness in the elderly cases under investigation.

Enrollment: 3 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients of dyslipidemia with high triglyceride level (200 to 499 mg/100 ml).
• Total cholesterol level more than 200 mg/100 ml
• Male and female
• Age 35 - 70 years

Exclusion criteria

• • Hypersensitivity of drugs
• Liver toxicity
• -Patients suffering from renal dysfunction

Trial design

3 participants in 5 patient groups

Simvastatin

Ezetimibe

Treatment:

Drug: Ezetimibe 10mg

Omega -3 fatty acids-

Simvastatin+ Ezetimibe

Treatment:

Drug: Ezetimibe 10mg

Simvastain + ezetimibe + omega

Treatment:

Drug: Ezetimibe 10mg