Investigate the Relationship Between Inflammatory and Coagulation in SAH CSF

Zhejiang University

Status: Completed

Conditions: Subarachnoid Hemorrhage, Aneurysmal

Treatments: Diagnostic Test: Lumbar puncture

Study type: Observational

Funder types: Other

Identifiers

NCT04938414

2020-892

Details and patient eligibility

About

Investigate the role of inflammasome and blood coagulation response in human cerebrospinal fluid after subarachnoid hemorrhage.

Full description

Investigate the role of inflammasome and blood coagulation response in human cerebrospinal fluid after subarachnoid hemorrhage (SAH).

1.40 patients with SAH will be included. The CSF will used for ELISA test for inflammatory factors and cogulation factors.

2.CSF obtained from 4 patients with non-neuroloogical disease with 4 addittional SAH patients will be used for Mass Spectrometry

Enrollment: 40 patients

Sex: All

Ages: 30 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• SAH patients with modified Fisher Scale 3-4.

Exclusion criteria

• Patients with history of CNS disease (e.g., stroke, traumatic brain injury, CNS infection) or accompanied by serious comorbidities before SAH onset (e.g., severe coagulation disorders, malignant tumor, uncontrollable heart disease, and hypertension) or other organ dysfunctions within 6 months were excluded from the study

Trial design

40 participants in 2 patient groups

subarachnoid hemorrhage

Description:

Patients with subarachnoid hemorrhage

Treatment:

Diagnostic Test: Lumbar puncture

Control

Description:

patients with non-neurological diseases

Treatment:

Diagnostic Test: Lumbar puncture