Investigating a Model for Acute Ischemic Pain in Humans

Ludwig Maximilian University of Munich

Status: Completed

Conditions: Peripheral Arterial Disease

Treatments: Other: acute ischemic pain

Study type: Interventional

Funder types: Other

Identifiers

NCT02192242

001

Details and patient eligibility

About

The pathophysiology of acute ischemic pain is not well established. The aim of the present study was to investigate acute ischemic pain in humans with a view to establish a scientific model to perform future studies. The investigators examined whether peripheral nerve damage and acute inflammation occur during short episodes of acute ischemia.

Enrollment: 11 patients

Sex: All

Ages: 40+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients over 40 years
• unilateral femoral-popliteal PAD, Fontaine grade II

Exclusion criteria

• patients with pain at rest or other pain origin
• diabetic polyneuropathy
• deep vein thrombosis

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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11 participants in 1 patient group

Acute ischemic pain

Experimental group

Description:

acute ischemic pain was induced by treadmill testing in all patients investigated

Treatment:

Other: acute ischemic pain