Investigating HD-tDCS in Improving Word Finding and Memory Retrieval in Individuals With MCI

The University of Texas System (UT)

Status: Withdrawn

Conditions: Mild Cognitive Impairment

Treatments: Device: Sham; Device: Active frontal; Device: Active parietal

Study type: Interventional

Funder types: Other

Identifiers

NCT03446508

18-21

Details and patient eligibility

About

This study is attempting to improve word finding and memory retrieval problems persons with mild cognitive impairment (MCI) may have.

Full description

This study attempts to improve word finding and memory retrieval problems in persons with mild cognitive impairment (MCI). To remember and find words, the brain has to search for the correct memory and MCI can negatively affect this search. Studies have suggested that low level electrical stimulation of the memory retrieval circuit can improve memory recall. The purpose of this study is to find the exact influence of multi-electrode or High Definition transcranial Direct Current Stimulation (HD-tDCS) by targeting a frontal and a parietal brain area, and their roles in memory retrieval/word finding in MCI. By modulating ongoing activity in 6 sessions of HD-tDCS the study investigates whether HD-tDCS may be used as a way to improve memory retrieval/word finding evaluated by cognitive measures and electroencephalography (EEG) measures before the first session and after the last session of HD-tDCS with a follow-up session 1-month after the stimulation procedure.

Sex: All

Ages: 40 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age between 40 and 90
2. Capable of understanding and signing an informed consent
3. Experiencing severe memory problems

Exclusion criteria

1. Severe organic co-morbidity
2. Pace maker / defibrillator
3. Pregnancy

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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0 participants in 3 patient groups

Active frontal

Experimental group

Description:

Active HD-tDCS

Treatment:

Device: Active frontal

Active parietal

Experimental group

Description:

Active HD-tDCS

Treatment:

Device: Active parietal

Sham control

Sham Comparator group

Description:

Sham HD-tDCS

Treatment:

Device: Sham