Investigating STAT3 as a Driver of Pathology in Periodontitis

University of Chile

Status: Completed

Conditions: Periodontitis

Treatments: Other: no intervention

Study type: Observational

Funder types: Other

Identifiers

NCT05506098

11180389

FONDECYT 11180389 (Other Grant/Funding Number)

Details and patient eligibility

About

Periodontitis is a prevalent inflammatory condition that destroys tooth-supporting structures. This condition is associated with pro-inflammatory mediators that utilize STAT3 as an activator of specific genes related to inflammation and tissue destruction. STAT3 has not been studied in the context of periodontitis in humans. We propose that STAT3 is associated with periodontitis. This knowledge might help to further our understanding of periodontitis pathology

Enrollment: 28 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18-year-old, in good general health, and had no significant medical history.
• no history of diabetes or other diseases different than periodontitis.

Exclusion criteria

• Pregnancy and lactation
• Use of antibiotics, immunosuppressive agents, or probiotics within 3 months.

Trial design

28 participants in 2 patient groups

Healthy

Description:

Subjects without periodontitis

Treatment:

Other: no intervention

Periodontitis

Description:

Subjects with periodontitis

Treatment:

Other: no intervention